Effect of exercise training on plasma visfatin and eotaxin levels.

OBJECTIVE Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulin-mimetic effect. Eotaxin, which is an important chemokine in asthma, was recently reported to be associated with obesity in mice and humans. We evaluated the effect of exercise training on plasma visfatin and eotaxin levels in association with cardiovascular risk factors. DESIGN Forty-eight non-diabetic Korean women were evaluated before and after a 12 week exercise program including aerobic exercise (45 min/session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week. RESULTS Plasma visfatin concentrations were elevated in obese subjects (body mass index, BMI> or =25 kg/m2) when compared with non-obese subjects (16.4 +/- 13.4 ng/ml vs 7.7 +/- 5.2 ng/ml, P = 0.006), and eotaxin concentrations were elevated in subjects with central obesity (waist circumference, WC> or =80 cm) when compared with those without central obesity (73.6 +/- 17.8 pg/ml vs 64.2 +/- 4.2 pg/ml, P = 0.005). In multiple regression analyses, visfatin levels were associated with BMI (R2 = 0.255) and eotaxin levels were associated with WC and body weight (R2 = 0.307). After the exercise program, body weight, blood pressure, fasting glucose, and insulin resistance of participants were decreased. Furthermore, plasma visfatin levels were significantly decreased from 13.6 +/- 12.0 to 7.7 +/- 7.9 ng/ml (P = 0.026) and eotaxin levels were reduced from 72.0 +/- 16.7 to 66.9 +/- 14.2 pg/ml (P = 0.018). CONCLUSIONS Exercise training with weight loss induced a significant reduction of plasma visfatin and eotaxin levels in non-diabetic Korean women.